Creased earlobes

Six Unusual Signs That May Indicate Heart Disease

The heart, so integral to life, sits in its protective cage in the chest, going about its work without any external sign to the owner.

In the West, where one in four people die of cardiovascular disease, the importance of keeping the heart in good working order is hard to overstate. Sadly, the first sign many people have that their heart isn’t in good working order is when they have a heart attack.

Although you can’t see your heart beating in your chest — not without specialist imaging technology, at least — there are visible, external signs that can indicate if something is wrong with your heart, before you suffer from a life-changing — or ending — “cardiovascular event”.

1. Creased earlobes

One such external indicator is diagonal creases on the earlobes — known as Frank’s sign, named after Sanders Frank, an American doctor who first described the sign. Studies have shown that there is an association with the visible external crease on the earlobe and increased risk of atherosclerosis, a disease where plaque builds up inside your arteries.

Over 40 studies have demonstrated an association between this feature of the ear and an increased risk of atherosclerosis. It is not clear what the cause of the association is, but some have postulated that it is to do with a shared embryological origin. Most recently, it has been seen that these creases are also implicated in cerebrovascular disease — disease of the blood vessels in the brain.

2. Fatty bumps

Another external indicator of heart issues is yellow, fatty bumps — known clinically as “xanthomas” — that can appear on the elbows, knees, buttocks or eyelids. The bumps themselves are harmless, but they can be a sign of bigger problems.

The mechanism that causes these fatty deposits in tissues is understood and it holds an iconic place in medicine as it led to the development of one of the blockbuster group of drugs that reduce cholesterol: statins.

3. Clubbed fingernails

A phenomenon known as digital clubbing may also be a sign that all is not well with your heart. This is where the fingernails change shape, becoming thicker and wider, due to more tissue being produced. The change is usually painless and happens on both hands.

Clubbing of the fingers is the oldest known medical symptom. It was first described by Hippocrates in the fifth-century BC. This is why clubbed fingers are sometimes known as Hippocratic fingers.

4. Halo around the iris

Fat deposits may also be seen in the eye, as a grey ring around the outside of the iris, the coloured part of the eye.

About 45% of people over the age of 40 have this fatty halo around their iris, rising to about 70% of people over the age of 60. The presence of this fatty ring has been shown to be associated with some of the risk factors for coronary heart disease.

5. Rotten gums and loose teeth

The state of your oral health can also be a good predictor of the state of your cardiovascular health. The mouth is full of bacteria, both good and bad.

Studies have shown that tooth loss and inflamed gums (periodontitis) are markers of heart disease.

6. Blue lips

Another health indicator from the mouth is the colour of your lips. The lips are usually red, but they can take on a bluish colour (cyanosis) in people with heart problems, due to the failure of the cardiovascular system to deliver oxygenated blood to tissues.

Adam Taylor is director of the Clinical Anatomy Learning Centre and a senior lecturer at Lancaster University.